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verified live · 20h ago
nullary
Negative results intelligence for drug discovery — query measured failures via MCP.
Tools
35
GitHub stars
—
Installs / wk
—
Licence
—
Transport
streamable-http
Last checked
20h ago
Tools & capabilities
35 toolsRead from the running server on 20h ago.
get_compound
read-only
tierlimitoffsetchembl_idinchi_keypubchem_cid
A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources. A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.
get_coverage
read-only
Per-modality and per-source coverage stats (honest Phase-1 numbers). Per-modality and per-source coverage stats (honest Phase-1 numbers).
get_finding_provenance
read-only
id*
Full provenance + detail for a single finding by id. Full provenance + detail for a single finding by id.
get_model_card
read-only
target*
Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.… Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).
get_target_landscape
read-only
target*
Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over… Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).
list_models
read-only
Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC. Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.
list_top_targets
read-only
limitfamily
Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel… Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).
search_adc_linker_failures
read-only
tierlimitoffsettargetoutcomecompound
ADC failures attributed to linker chemistry. ADC failures attributed to linker chemistry.
search_admet_failures
read-only
tierlimitoffsettargetoutcomecompound
Small-molecule ADMET failures. Small-molecule ADMET failures.
search_admet_failures_all_modalities
read-only
tierlimitoffsettargetoutcomecompound
ADMET failures across ALL modalities. ADMET failures across ALL modalities.
search_ancestry_specific_failures
read-only
tierlimitoffsettargetoutcomecompound
Ancestry-specific CRISPR failures. Ancestry-specific CRISPR failures.
search_bispecific_format_failures
read-only
tierlimitoffsettargetoutcomecompound
Bispecific format/engineering failures. Bispecific format/engineering failures.
search_developability_failures
read-only
tierlimitoffsettargetoutcomecompound
Antibody developability failures. Antibody developability failures.
search_drug_drug_interaction_failures
read-only
tierlimitoffsetoutcomecompound
Drug-drug interaction failures. Drug-drug interaction failures.
search_failed_adcs
read-only
tierlimitoffsettargetoutcomecompound
ADCs that failed at any stage. ADCs that failed at any stage.
search_failed_bispecifics
read-only
tierlimitoffsettargetoutcomecompound
Bispecifics that failed at any stage. Bispecifics that failed at any stage.
search_failed_clinical_antibodies
read-only
tierlimitoffsettargetoutcomecompound
Discontinued/terminated clinical antibodies. Discontinued/terminated clinical antibodies.
search_failed_essentiality_screens
read-only
tierlimitoffsettargetoutcomecompound
Non-dependency / failed essentiality screens. Non-dependency / failed essentiality screens.
search_failed_guides
read-only
tierlimitoffsettargetoutcomecompound
Failed/ineffective CRISPR guides. Failed/ineffective CRISPR guides.
search_failed_oligonucleotides
read-only
tierlimitoffsettargetoutcomecompound
ASOs/siRNAs that failed engagement/developability. ASOs/siRNAs that failed engagement/developability.
search_failed_peptide_therapeutics
read-only
tierlimitoffsettargetoutcomecompound
Failed peptide therapeutics. Failed peptide therapeutics.
search_failed_protacs
read-only
tierlimitoffsettargetoutcomecompound
PROTACs that failed degradation/ternary/permeability. PROTACs that failed degradation/ternary/permeability.
search_failed_replications
read-only
tierlimitoffsettargetoutcomecompound
Findings that failed to replicate. Findings that failed to replicate.
search_failed_selectivity
read-only
tierlimitoffsettargetoutcomecompound
Small molecules that failed selectivity. Small molecules that failed selectivity.
search_failed_vaccines
read-only
tierlimitoffsettargetoutcomeindication
Failed/terminated vaccines (by pathogen/indication). Failed/terminated vaccines (by pathogen/indication).
search_inactive_compounds
read-only
tierlimitoffsettargetoutcomecompound
Inactive small-molecule compound-target pairs. Inactive small-molecule compound-target pairs.
search_indication_history
read-only
tierlimitoffsetindication*
ALL failed approaches for an indication across every modality. ALL failed approaches for an indication across every modality.
search_mechanism_failures
read-only
tierlimitoffsettargetoutcomecompound
Approaches that failed for a mechanism (by target). Approaches that failed for a mechanism (by target).
search_oligo_delivery_failures
read-only
tierlimitoffsettargetoutcomecompound
Oligonucleotide delivery failures. Oligonucleotide delivery failures.
search_pathogen_history
read-only
tierlimitoffsetpathogen*
Vaccine + antimicrobial + antibody failures for a pathogen. Vaccine + antimicrobial + antibody failures for a pathogen.
search_peptide_stability_issues
read-only
tierlimitoffsettargetoutcomecompound
Peptide stability/half-life failures. Peptide stability/half-life failures.
search_protac_e3_issues
read-only
tierlimitoffsettargetoutcomecompound
PROTAC E3-ligase recruitment / ternary failures. PROTAC E3-ligase recruitment / ternary failures.
search_safety_failures
read-only
tierlimitoffsettargetoutcomecompound
Clinical/preclinical safety failures across modalities. Clinical/preclinical safety failures across modalities.
search_target_history
read-only
tierlimitoffsettarget*
ALL failed approaches against a target across every modality. ALL failed approaches against a target across every modality.
search_vaccine_immunogenicity_failures
read-only
tierlimitoffsettargetoutcomecompound